To rotate the Intuos 5 for sinister left-handed people:
$ xsetwacom set "Wacom Intuos5 M Pen stylus" Rotate half
$ xsetwacom set "Wacom Intuos5 M Pen eraser" Rotate half
$ xsetwacom set "Wacom Intuos5 M Pen cursor" Rotate half
$ xsetwacom set "Wacom Intuos5 M Pen pad" Rotate half
To get these commands to run at startup, I added them to $HOME/.profile (after trying .bashrc and .Xsession, neither of which worked [running Xubuntu]).
Adapted from notes at linuxwacom sourceforge site.
Dual-screen Setup
(Updated 24 Feb 2013)
After getting an nVidia GPU, I had much more luck getting dual-monitors to work than with either AMD or Intel graphics. By default though the tablet will span across all monitors. If you want to reduce this to a single monitor, do this:
$ xsetwacom set "Wacom Intuos5 M Pen stylus" MapToOutput HEAD-0
Note: if you're not using nVidia drivers, the output of xrandr will give you the names of your screens, rather than HEAD-0, HEAD-1, etc. as shown above.
